手性分析；中藥與天然藥物質量控制；有機小分子及體內藥物分析；多肽及反義核酸藥物研究與評價

有關手性分析技術的圖書介紹(國外-英文電子版下載)

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1 Chiral Separation Techniques: A Practical Approach, 3rd, Completely Revised and Updated Edition

Edited by G. Subramanian

Copyright ? 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

ISBN: 978-3-527-31509-3
641 pages
January 2007

1 Method Development and Optimization of Enantioseparations
Using Macrocyclic Glycopeptide Chiral Stationary Phases
1.1 Introduction
1.2 Structural Characteristics of Macrocyclic Glycopeptide CSPs
1.3 Enantioselectivity as a Function of Molecular Recognition
1.4 Complementary Effects
1.5 Method Development
1.6 Optimization Procedures
1.7 Amino Acid and Peptide Analysis
1.8 Conclusion
2 Role of Polysaccharides in Chiral Separations
by Liquid Chromatography and Capillary Electrophoresis
3 Analytical and Preparative Potential
of Immobilized Polysaccharide-derived Chiral Stationary Phases
4 Chiral Separations Using Supercritical Fluid Chromatography
5 Chiral Separation by Ligand Exchange *
6 Advances in Simulated Moving Bed Chromatographic
Separations
7 Less Common Applications of Enantioselective HPLC Using
the SMB Technology in the Pharmaceutical Industry
8 Enantiomer Separation by Chiral Crown Ether Stationary
Phases
9 Enantioselective Separation of Amino Acids and Hydroxy
Acids by Ligand Exchange with Copper(II) Complexes
in HPLC (Chiral Eluent) and in Fast Sensing Systems
10 Enantiomer Separation by Capillary Electrophoresis
11 Counter-current Chromatography
in the Separation of Enantiomers
12 Separation of Enantiomers Using Molecularly Imprinted
Polymers
13 Enantioselective Biosensors
14 Chiral Analysis in Capillary Electrochromatography (CEC)
and CEC Coupled to Mass Spectrometry *)
15 Chiral Analysis Using Polymeric Surfactants
in Micellar Electrokinetic Chromatography (MEKC)
and MEKC Coupled to Mass Spectrometry *)
16 Polarimeter Chiral Detectors in Enantioseparations
17 Preparative Chiral Chromatography –
a Powerful and Efficient Tool in Drug Discovery

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2 Chiral Chromatography

Author: Thomas E. Beesley
ISBN: 0471974277

Publisher: John Wiley & Sons

Summary:
Chiral Chromatography Thomas E. Beesley Advanced Separation Technologies Inc., Whippany, New Jersey, USA Raymond P. W. Scott Chemistry Department, Georgetown University, Washington DC, USA and Chemistry Department, Birkbeck College, University of London, UK Analytical techniques based on separation processes, such as chromatography and electrophoresis, are finding a growing range of applications in chemical, pharmaceutical and clinical laboratories. The Wiley Separation Science Series provides the analyst in these laboratories with well-focused books covering individual techniques, so that they can be applied more efficiently and effectively to contemporary analytical problems. The different enantiomers of a drug can exhibit widely different physiological activity in degree and nature. As a result, the separation and identification of enantiomers is now a very important analytical problem and chiral chromatography is the natural technique to apply to the resolution of such mixtures. Chiral Chromatography provides the reader with a basic understanding of the nature of chromatographic separations and relates the principles specifically to the separation of enantiomers. The following information is included:
* chiral separations involving both gas and liquid chromatography
* descriptions of the apparatus used for both techniques
* detailed discussion on the retention mechanism that results in chiral selectivity
* the structure and synthesis of a wide range of chirally active stationary phases used in both gas and liquid chromatography
* preparative applications for large scale purification of enantiomers
* applications of capillary electrophoresis and capillary electrochromatography.
In addition to the above, a large number of examples of the separation of both commercially and physiologically interesting chiral mixtures are given, as is a detailed discussion on the mechanism of selectivity of each example. Thomas Beesley was founder and is the CEO for a leading manufacturer of chiral stationary phases and has published papers on TLC, HPLC and chiral separations involving cyclodextrins. He has also coauthored papers with Daniel W. Armstrong, an expert on modern cyclodextrin columns. Raymond Scott has worked in the field of separation science for over 40 years and has contributed extensively to the development of both gas and liquid chromatography publishing over 160 papers on the subjects.

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http://www.ftp2share.com/file/35978/www.forumakademi.org.html

3 Thin Layer Chromatography in Chiral Separations and Analysis, Volume 98

Publisher: CRC
Number Of Pages: 436
Publication Date: 2007-06-22
Sales Rank: 3390461
ISBN / ASIN: 0849343690
EAN: 9780849343698
Binding: Hardcover
Manufacturer: CRC
Studio: CRC

Investigation and control of chirality, which is executed almost exclusively using chromatographic techniques, ranks among the most difficult separation tasks. As the first book devoted to this topic, Thin Layer Chromatography in Chiral Separations and Analysis presents updated information on this important field. The first part of this book discusses the problem of chirality in general and the technical possibilities of carrying out enantiomer separations in detail. Addressing significant application areas, the second part of the text provides a comprehensive overview of enantioseparations and densitometric analyses that have been successfully achieved using thin layer chromatography.

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